Located in Hastings, Nebraska, Heartland Veterinary Supply & Pharmacy started as a Veterinary Clinic in 1981, specializing in the health and wellness of the equine, canine and feline species. A dosing device is strongly recommended for the safety of the handler and accuracy of dosing your animal. It may be used to suppress and prevent the signs of oestrus in mares, which may be particularly useful early in the breeding season. REGUMATE® Equinos USO VETERINARIO. Regumate Equine is a hormonal treatment for mares containing the synthetic progestagen altrenogest. Further information is available on request. The oral synthetic progestin altrenogest (Regumate Equine, MSD Animal Health) is the only treatment licensed for the suppression of oestrus in mares in the UK. [2][3] Altrenogest is the 17α-allylated derivative of the AAS trenbolone (and hence can also be referred to as allyltrenbolone or allyltrienolone), which itself is the 9,11-didehydro analogue of the AAS nandrolone (19-nortestosterone). ReguMate® is a registered trademark of Merck Animal Health Dosage and Directions While wearing protective gloves, remove shipping cap and seal; replace with enclosed plastic dispensing cap. Pregnant women or women who suspect they are pregnant should not handle Regu-Mate®. Regumate® is a man made progestane, altrenogest, that has strong progesterone properties and can be placed in the feed. [10], Altrenogest, also known as 17α-allyl-19-nor-δ9,11-testosterone or as 17α-allylestra-4,9,11-trien-17β-ol-3-one, is a synthetic estrane steroid and derivative of 19-nortestosterone and 17α-allyltestosterone, or of 17α-allyl-19-nortestosterone. Pregnant women or women who suspect they are pregnant should not handle Regu-Mate®. Veterinarian Prescription (Rx) Required  Storage. It may help even out the disposition of mares just generally out of sorts, touchy and difficult to work with throughout the cycle because of wide hormone swings or hormonal imbalances. Regu-Mate ® (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. WITHDRAWAL PERIOD. [8], Although very potent in both activities in vitro, the AR/PR activational potency ratio of altrenogest was in the same range as that of other 19-nortestosterone progestins such as norethisterone, noretynodrel, norgestrel, and allylestrenol (ratio for all < 1.0), whereas the AR/PR activational potency ratio of its 17α-deallylated AAS analogue trenbolone was, at 64, profoundly increased (although the ratio of metribolone (the 17α-methylated variant of altrenogest), at 0.56, was almost the same as that of altrenogest). Altrenogest is used for two purposes: to suppress the estrus cycle in mares that are in heavy training or competition, and to induce estrus for the purpose of facilitating planned breedings in mares. This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. … REGU-MATE (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. While wearing protective gloves, remove shipping cap and seal; replace with enclosed plastic dispensing cap. Use to schedule estrus and breeding to maximize breeding efficiency. Replace cover on bottle dispensing tip to prevent leakage. We will gladly match any competitors’ current advertised price. Contains altrenogest 2.2 mg/mL in an oily solution. Mares on Regumate to maintain pregnancy can have their progesterone level drawn to see if she needs to continue on the regumate as the reugmate is synthetic and not recognized by the test, thus the actual level indicated by the test is the true reading that the pregnancy is producing. [11] On the other hand, minor potential anabolic/androgenic effects have been suggested for altrenogest in pigs. Species: Horses and other equidae. The Heartland Staff is dedicated to fast, courteous service. All Rights Reserved. Regumate, (approved 1983) NADA 131-310, Merck Animal Health, 800-211-3573 Ovamed, (previously Altresyn, approved 2012) ANADA 200-481, Bimeda, Inc., 888 … Every purchase you make at HeartlandVetSupply.com is covered by our satisfaction guarantee. Use to schedule estrus and breeding to maximize breeding efficiency. Regumate is the brand name for the hormone altrenogest. [2][3][4][5][6] It is available for veterinary use in both Europe (as Regumate) and the United States (as Matrix).[7]. Administer orally with dose syringe or by placing directly on feed. Regu-Mate effectively suppresses estrus in 95 percent of mares after 3 days of treatment. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. Regumate is the most widely used drug in controlling mare behavior. Remove cover from bottle dispensing tip and connect luer lock syringe (without needle). Detach syringe and administer solution orally at the rate of 1mL per 110 pounds body weight (0.044 mg/kg) once daily for 15 consecutive days. Regu-Mate Suppression of estrus allows for a predictable occurrence of estrus … Regumate Equine is a liquid suspension used for the suppression or prevention of oestrus in mares. Altrenogest, sold under the brand names Swinemate and Altren manufactured by Aurora Pharmaceutical and Regumate manufactured by Merck, is a progestin of the 19-nortestosterone group which is widely used in veterinary medicine to suppress or synchronize estrus in horses and pigs. [2][3][4], C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(CC=C)O, InChI=1S/C21H26O2/c1-3-10-21(23)12-9-19-18-6-4-14-13-15(22)5-7-16(14)17(18)8-11-20(19,21)2/h3,8,11,13,18-19,23H,1,4-7,9-10,12H2,2H3/t18-,19+,20+,21+/m1/s1, https://www.drugs.com/international/altrenogest.html, Algestone acetophenide (dihydroxyprogesterone acetophenide), Flugestone acetate (flurogestone acetate), Gestonorone caproate (gestronol hexanoate), Segesterone acetate (nestorone, elcometrine), 17α-Methyl-11-deoxycorticosterone acetate, 16-Methylene-17α-hydroxyprogesterone acetate, 17α-Hydroxyprogesterone (hydroxyprogesterone), Hydroxyprogesterone caproate (hydroxyprogesterone hexanoate), Hydroxyprogesterone heptanoate (hydroxyprogesterone enanthate), Hydroxyprogesterone heptanoate benzilic acid hydrazone, 11β-Methyl-19-nortestosterone dodecylcarbonate, Normethandrone (methylestrenolone, normethandrolone, normethisterone), 11-Deoxycortisone (21-hydroxyprogesterone), 11-Deoxycortisol (17α,21-dihydroxyprogesterone), https://en.wikipedia.org/w/index.php?title=Altrenogest&oldid=992189088, Chemical pages without DrugBank identifier, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, Allyltrenbolone; Allyltrienolone; RU-2267; RH-2267; A-35957; A-41300; 17α-Allylestra-4,9,11-trien-17β-ol-3-one; 17α-Allyl-19-nor-δ, This page was last edited on 3 December 2020, at 23:52. Provides safe, effective suppression of estrus in mares — 95% effective after 3 days of treatment. Altrenogest is used for two purposes: to suppress the estrus cycle in mares that are in heavy training or competition, and to induce estrus for the purpose of facilitating planned breedings in mares. If you are not completely satisfied, please contact us within 30 days. [8], According to its manufacturer Roussel Uclaf, altrenogest has weak anabolic and androgenic activity equivalent to 1/20th of that of testosterone. REGUMATE® Patrick M. McCue DVM, PhD, Diplomate American College of Theriogenologists Regumate® is the trade name for a synthetic hormone called altrenogest. It allows performance horses to compete at their best with a 15-day regimen. Shop for Altrenogest for equines. Regumate® Equine 2,2mg/ml. Regumate Equine, MIKSTUR, oppløsning: Styrke Dyreart Pakning Varenr SPC 1 R.gr. Milk: Not permitted for use in lactating animals producing milk for human consumption. [2][3], Altrenogest has been marketed as Regumate since the early 1980s. This will help for easy delivery to either the base of the mare's tongue or on the mare's feed ration. It can be used to prevent or supress the oestrus cycle in mares, restore a regular oestrus cycle, and may also be used as a strategic tool to aid with selective or planned breeding. The sensitivity of testing has increased dramatically since testing procedures were initiated. It’s easy to administer – orally or top-dressed on grain. Altrenogest, der Wirkstoff von Regumate ® Equine ist ein oral wirksames Progestagen. [8] In the study, it showed an EC50 of 0.64 nM for the AR and 688% of the relative activational potency of testosterone and an EC50 of 0.3 nM and 1,300% of the relative activational potency of progesterone, with an AR/PR activational potency ratio of 0.53. Regumate Equine is a hormonal medication for mares, distributed in the UK by MSD Animal Health. Altrenogest for horses, 60 mg/ml injectable (50ml) by NexGen is effective in normally cycling mares for minimizing the necessity for estrus detection, for the synchronization of estrus, and permitting scheduled breeding. For a syringe to take the fluid out of the bottle please click here. Regumate® is occasionally administered off-label to stallions in an attempt to suppress undesirable male behavioral characteristics ADD-- Zakiit, regumate is legal for competitions- at least every competition I've ever been in/heard of.